Mechanisms of patulin toxicity under conditions that inhibit yeast growth [Erratum: 2007 Feb. 21, v. 55, no. 4, p. 1648.]

Authors:
Iwahashi, Y.
Hosoda, H.
Park, J.H.
Lee, J.H.
Suzuki, Y.
Kitagawa, E.
Murata, S.M.
Jwa, N.S.
Gu, M.B.
Iwahashi, H.
Type: Journal Article
Year of publication: 2006
Source: USDA
Collected from: AGRIS
Subject:
agricultural products
products
Description:Patulin, 4-hydroxy-4H-furo[3,2c]pyran-2(6H)-one, is one of the best characterized and most widely disseminated mycotoxins found in agricultural products. Nonetheless, the mechanisms by which patulin causes toxicity are not well understood. Thus, the cytotoxicity of patulin was characterized by analysis of the yeast transcriptome upon challenge with patulin. Interestingly, patulin-induced yeast gene expression profiles were found to be similar to gene expression patterns obtained after treatment with the antifungal agricultural chemicals thiuram, maneb, and zineb. Moreover, patulin treatment was found to activate protein degradation, especially proteasome activities, sulfur amino acid metabolism, and the defense system for oxidative stress. Damage to DNA by alkylation was also suggested, and this seemed to be repaired by recombinational and excision repair mechanisms. Furthermore, the results provide potential biomarker genes for the detection of patulin in agricultural products. The results suggest the possibility of applying the yeast transcriptome system for the evaluation of chemicals, especially for natural chemicals that are difficult to get by organic synthesis.
 

Related Resources

Financial assessment of a new soil heating technology for off-season Asparagus production

Provider: 
Subject: 
products
agricultural products
agricultural economics

Risk Analysis for Off-season Greenhouse Tomato Production

Provider: 
Subject: 
products
agricultural products
plant products
socioeconomic development
agricultural development
economics
agricultural economics
agriculture
agricultural practices

Innovation implementation strategies for consumer driven fruit supply chains

Provider: 
Subject: 
products
agricultural products
socioeconomic development
rural development
agricultural development
economics
agricultural economics
trade
agriculture
agricultural practices

Moisture Ratio Prediction in Drying Process of Agricultural Products: A New Correlation Model

Provider: 
Subject: 
agricultural products
products
Collected from: 

review on the indicator water footprint for the EU28

Provider: 
Subject: 
agricultural products
products
Collected from: 

Reduction of Dichlorvos and Omethoate Residues by O2 Plasma Treatment

Provider: 
Subject: 
agricultural products
products
Collected from: 

AGRERI Library

Financial assessment of a new soil heating technology for off-season Asparagus production

Provider: 
Subject: 
products
agricultural products
agricultural economics

Risk Analysis for Off-season Greenhouse Tomato Production

Provider: 
Subject: 
products
agricultural products
plant products
socioeconomic development
agricultural development
economics
agricultural economics
agriculture
agricultural practices

Innovation implementation strategies for consumer driven fruit supply chains

Provider: 
Subject: 
products
agricultural products
socioeconomic development
rural development
agricultural development
economics
agricultural economics
trade
agriculture
agricultural practices

External Library

Moisture Ratio Prediction in Drying Process of Agricultural Products: A New Correlation Model

Provider: 
Subject: 
agricultural products
products
Collected from: 

review on the indicator water footprint for the EU28

Provider: 
Subject: 
agricultural products
products
Collected from: 

Reduction of Dichlorvos and Omethoate Residues by O2 Plasma Treatment

Provider: 
Subject: 
agricultural products
products
Collected from: